Many medications are cleared by the body through the kidneys. In people with renal impairment, this process can be slowed, potentially leading to toxic levels of a drug building up in the body. To avoid this, medicines excreted by the kidneys have dosing recommendations. Renal function can change over time but in acute care settings, this can be dynamic, with some patients experiencing a rapid decline in renal function during their acute illness. Here, drug errors are common with only 40% of medicines which need a dose adjustment having this made when first prescribed. This can impact on patient safety.

​To improve how medicines are prescribed during acute kidney injury in urgent and emergency care settings, PIONEER, with the NIHR Midlands Patient Safety Research Collaboration, has curated a highly granular dataset containing 449,472 hospitalised patients. The data includes demographics, vital signs (early warning score components and BMI), comorbidities, laboratory results and all medications, including dose and route. The dataset captures any prescribing alerts, and outcomes, including dialysis, mortality and readmission.

Geography: The West Midlands (WM) has a population of 6 million & includes a diverse ethnic & socio-economic mix. UHB is one of the largest NHS Trusts in England, providing direct acute services & specialist care across four hospital sites, with 2.2 million patient episodes per year, 2750 beds & > 120 ITU bed capacity. UHB runs a fully electronic healthcare record (EHR) (PICS; Birmingham Systems), a shared primary & secondary care record (Your Care Connected) & a patient portal “My Health”.

Data set availability: Data access is available via the PIONEER Hub for projects which will benefit the public or patients. This can be by developing a new understanding of disease, by providing insights into how to improve care, or by developing new models, tools, treatments, or care processes. Data access can be provided to NHS, academic, commercial, policy and third sector organisations. Applications from SMEs are welcome. There is a single data access process, with public oversight provided by our public review committee, the Data Trust Committee. Contact pioneer@uhb.nhs.uk or visit www.pioneerdatahub.co.uk for more details.

Available supplementary data: Matched controls; ambulance and community data. Unstructured data (images). We can provide the dataset in OMOP and other common data models and can build synthetic data to meet bespoke requirements.

Available supplementary support: Analytics, model build, validation & refinement; A.I. support. Data partner support for ETL (extract, transform & load) processes. Bespoke and “off the shelf” Trusted Research Environment (TRE) build and run. Consultancy with clinical, patient & end-user and purchaser access/ support. Support for regulatory requirements. Cohort discovery. Data-driven trials and “fast screen” services to assess population size.