Sepsis presents a significant medical challenge with high morbidity and mortality rates, necessitating prompt and effective management. Sepsis is not always easy to diagnose, especially in its early stages. To improve outcomes from sepsis, those with suspected, severe infections receive antibiotics, with guidelines highlighting that these should be given as early as possible. However, this must be balanced with appropriate antibiotic stewardship. Broad spectrum antibiotic use is associated with severe side effects and adverse outcomes, especially in older people, and antibiotic resistance increases with increasing antibiotic use.

The NIHR Birmingham Biomedical Research Centre Infections and acute care theme has curated a highly granular dataset of 1,589,709 hospital spells, containing 647,934 unique patients with suspected infections, with PIONEER. The data includes demographics, co-morbidities, presenting symptoms, serial physiology and acuity, all investigations and treatments and all outcomes including admission to intensive care, death and readmission. All medications are included with dose and route.

Geography: The West Midlands (WM) has a population of 6 million & includes a diverse ethnic & socio-economic mix. UHB is one of the largest NHS Trusts in England, providing direct acute services & specialist care across four hospital sites, with 2.2 million patient episodes per year, 2750 beds & > 120 ITU bed capacity. UHB runs a fully electronic healthcare record (EHR) (PICS; Birmingham Systems), a shared primary & secondary care record (Your Care Connected) & a patient portal “My Health”.

Data set availability: Data access is available via the PIONEER Hub for projects which will benefit the public or patients. This can be by developing a new understanding of disease, by providing insights into how to improve care, or by developing new models, tools, treatments, or care processes. Data access can be provided to NHS, academic, commercial, policy and third sector organisations. Applications from SMEs are welcome. There is a single data access process, with public oversight provided by our public review committee, the Data Trust Committee. Contact pioneer@uhb.nhs.uk or visit www.pioneerdatahub.co.uk for more details.

Available supplementary data: Matched controls; ambulance and community data. Unstructured data (images). We can provide the dataset in OMOP and other common data models and can build synthetic data to meet bespoke requirements.

Available supplementary support: Analytics, model build, validation & refinement; A.I. support. Data partner support for ETL (extract, transform & load) processes. Bespoke and “off the shelf” Trusted Research Environment (TRE) build and run. Consultancy with clinical, patient & end-user and purchaser access/ support. Support for regulatory requirements. Cohort discovery. Data-driven trials and “fast screen” services to assess population size.