Allergy to penicillin is commonly reported. In the United Kingdom, 14% of hospitalised patients are reported to have a penicillin allergy however only about 5% of patients reporting a penicillin allergy are found to be truly allergic when this is investigated.

​Penicillin allergy has a significant impact on antibiotic prescribing. Here, broad spectrum non-penicillin antibiotics are more commonly used but these antibiotics are increasingly less effective during infections due to antimicrobial resistance. Research to understand any association between stated penicillin allergy, antimicrobial resistant and health outcomes is needed.

To investigate this (and related questions) PIONEER has curated a highly granular dataset of 17444 acute blood steam infection admissions in 15069 patients, supported by the NIHR. The data includes demography, diagnostic codes (ICD-10 & SNOMED-CT), presenting symptoms, serial physiology, investigations including microbiology, treatments and medications, stated allergies, intensive care,) and outcomes. The current dataset includes admissions from 2015 to 2020 but can be expanded to assess other timelines of interest.

Geography: The West Midlands (WM) has a population of 6 million & includes a diverse ethnic & socio-economic mix. UHB is one of the largest NHS Trusts in England, providing direct acute services & specialist care across four hospital sites, with 2.2 million patient episodes per year, 2750 beds & > 120 ITU bed capacity. UHB runs a fully electronic healthcare record (EHR) (PICS; Birmingham Systems), a shared primary & secondary care record (Your Care Connected) & a patient portal “My Health”.

Data set availability: Data access is available via the PIONEER Hub for projects which will benefit the public or patients. This can be by developing a new understanding of disease, by providing insights into how to improve care, or by developing new models, tools, treatments, or care processes. Data access can be provided to NHS, academic, commercial, policy and third sector organisations. Applications from SMEs are welcome. There is a single data access process, with public oversight provided by our public review committee, the Data Trust Committee. Contact pioneer@uhb.nhs.uk or visit www.pioneerdatahub.co.uk for more details.

Available supplementary data: Matched controls; ambulance and community data. Unstructured data (images). We can provide the dataset in OMOP and other common data models and can build synthetic data to meet bespoke requirements.

Available supplementary support: Analytics, model build, validation & refinement; A.I. support. Data partner support for ETL (extract, transform & load) processes. Bespoke and “off the shelf” Trusted Research Environment (TRE) build and run. Consultancy with clinical, patient & end-user and purchaser access/ support. Support for regulatory requirements. Cohort discovery. Data-driven trials and “fast screen” services to assess population size.