Smoking is a leading preventable cause of chronic diseases like circulatory disease, cancer, and chronic lung conditions, worsening outcomes in acute illnesses. Despite reductions from public health campaigns, 13-16% of the UK population still smoke, with higher rates in hospital admissions. Smoking-related admissions cost over £870,000 annually, prompting a focus on smoking cessation, particularly in secondary care, where targeted interventions are effective. Influenza often leads to severe complications in hospitals, such as ICU admission and death, especially in older adults and those with chronic respiratory conditions. Smoking increases risks of mortality and ICU admission in influenza cases, but UK-specific data, especially on seasonal influenza, is limited. Updated data on high-risk groups, including smokers, is crucial to guide interventions. This dataset of 26,047 admissions between Jan 2018 and Jul 2024 with influenza, includes demography, serial physiology, assessments, diagnostic codes (ICD-10 & SNOMED-CT), initial presentation, ventilation, ICU transfers, prescriptions and outcomes. Geography: The West Midlands (WM) has a population of 6 million & includes a diverse ethnic & socio-economic mix. UHB is one of the largest NHS Trusts in England, providing direct acute services & specialist care across four hospital sites, with 2.2 million patient episodes per year, 2750 beds & > 120 ITU bed capacity. UHB runs a fully electronic healthcare record (EHR) (PICS; Birmingham Systems), a shared primary & secondary care record (Your Care Connected) & a patient portal “My Health”. Data set availability: Data access is available via the PIONEER Hub for projects which will benefit the public or patients. This can be by developing a new understanding of disease, by providing insights into how to improve care, or by developing new models, tools, treatments, or care processes. Data access can be provided to NHS, academic, commercial, policy and third sector organisations. Applications from SMEs are welcome. There is a single data access process, with public oversight provided by our public review committee, the Data Trust Committee. Contact pioneer@uhb.nhs.uk or visit www.pioneerdatahub.co.uk for more details. Available supplementary data: Matched controls; ambulance and community data. Unstructured data (images). We can provide the dataset in OMOP and other common data models and can build synthetic data to meet bespoke requirements. Available supplementary support: Analytics, model build, validation & refinement; A.I. support. Data partner support for ETL (extract, transform & load) processes. Bespoke and “off the shelf” Trusted Research Environment (TRE) build and run. Consultancy with clinical, patient & end-user and purchaser access/ support. Support for regulatory requirements. Cohort discovery. Data-driven trials and “fast screen” services to assess population size.