Clinical studies have suggested a link between critical illness and cardiac events. Pre-clinical research has also suggested that critical illness is associated with the development of acute cardiac disease, with mechanisms including inflammation, changeable physiology and the use of medications and fluids which are associated with vascular damage. Understanding who might be at risk for poor cardiac outcomes following critical illness and how to predict cardiac events in real time might support new treatment strategies.

​To explore this further, PIONEER has curated a dataset of over 800 patients who have experienced an acute myocardial event during or shortly after an admission to intensive care. This includes serial, time-stamped physiology, blood results, investigations including ECGs and imaging, other cardiac diagnostic tests, all medications before, during and after the event, and outcomes, including death, length of stay and readmission. Data also include ventilatory support, SOFA score and APACHE II scores. This can be matched with a control population.

Geography: The West Midlands (WM) has a population of 6 million & includes a diverse ethnic & socio-economic mix. UHB is one of the largest NHS Trusts in England, providing direct acute services & specialist care across four hospital sites, with 2.2 million patient episodes per year, 2750 beds &

120 ITU bed capacity. UHB runs a fully electronic healthcare record (EHR) (PICS; Birmingham Systems), a shared primary & secondary care record (Your Care Connected) & a patient portal “My Health”.

Data set availability: Data access is available via the PIONEER Hub for projects which will benefit the public or patients. This can be by developing a new understanding of disease, by providing insights into how to improve care, or by developing new models, tools, treatments, or care processes. Data access can be provided to NHS, academic, commercial, policy and third sector organisations. Applications from SMEs are welcome. There is a single data access process, with public oversight provided by our public review committee, the Data Trust Committee. Contact pioneer@uhb.nhs.uk or visit www.pioneerdatahub.co.uk for more details.

Available supplementary data: Matched controls; ambulance and community data. Unstructured data (images). We can provide the dataset in OMOP and other common data models and can build synthetic data to meet bespoke requirements.

Available supplementary support: Analytics, model build, validation & refinement; A.I. support. Data partner support for ETL (extract, transform & load) processes. Bespoke and “off the shelf” Trusted Research Environment (TRE) build and run. Consultancy with clinical, patient & end-user and purchaser access/ support. Support for regulatory requirements. Cohort discovery. Data-driven trials and “fast screen” services to assess population size.