Approximately 10% of the population have a penicillin allergy label which is mostly self-reported. The symptoms causing patients to label themselves as being allergic arise from symptoms such as gastrointestinal upset, rash or altered taste. It is widely believed that only 10% of those with a SRPA have a true, immune-mediated penicillin allergy.

The reporting of a penicillin allergy, irrespective of whether this is true allergy or not, can alter antibiotic prescribing. Alternative prescriptions of non-beta-lactam antibiotics may be less efficacious in serious infections and patients may be at increased risk of secondary infections and poor outcomes.

To explore this, PIONEER, in collaboration with the HDRUK Medicines in Acute and Chronic Care Driver programme, has curated a dataset of over 37,000 admissions to intensive care, with self-reported allergies documented, as well as serial and highly granular data on presentation, acuity, physiology, investigations and all treatments and outcomes.

Geography: The West Midlands (WM) has a population of 6 million & includes a diverse ethnic & socio-economic mix. UHB is one of the largest NHS Trusts in England, providing direct acute services & specialist care across four hospital sites, with 2.2 million patient episodes per year, 2750 beds & > 120 ITU bed capacity. UHB runs a fully electronic healthcare record (EHR) (PICS; Birmingham Systems), a shared primary & secondary care record (Your Care Connected) & a patient portal “My Health”.

Data set availability: Data access is available via the PIONEER Hub for projects which will benefit the public or patients. This can be by developing a new understanding of disease, by providing insights into how to improve care, or by developing new models, tools, treatments, or care processes. Data access can be provided to NHS, academic, commercial, policy and third sector organisations. Applications from SMEs are welcome. There is a single data access process, with public oversight provided by our public review committee, the Data Trust Committee. Contact pioneer@uhb.nhs.uk or visit www.pioneerdatahub.co.uk for more details.

Available supplementary data: Matched controls; ambulance and community data. Unstructured data (images). We can provide the dataset in OMOP and other common data models and can build synthetic data to meet bespoke requirements.

Available supplementary support: Analytics, model build, validation & refinement; A.I. support. Data partner support for ETL (extract, transform & load) processes. Bespoke and “off the shelf” Trusted Research Environment (TRE) build and run. Consultancy with clinical, patient & end-user and purchaser access/ support. Support for regulatory requirements. Cohort discovery. Data-driven trials and “fast screen” services to assess population size.