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NHS England Secure Data Environment (SDE)

Introduction

{"type":"doc","content":[{"type":"paragraph","content":[{"type":"text","text":"The NHS England Secure Data Environment (SDE) is a secure data and research analysis platform. It gives approved researchers with approved projects secure access to NHS healthcare data for healthcare analysis. All patient information in the SDE is pseudonymised. It is part of the NHS Research SDE Network across England."}]},{"type":"paragraph","content":[{"type":"text","text":"To access the NHS England Secure Data Environment a valid Data Sharing Agreement is required. Start the process using our Data Access Request Service here: https://digital.nhs.uk/services/data-access-request-service-dars/process"}]},{"type":"paragraph","content":[{"type":"text","text":"Cost to access: We use a cost recovery model to calculate the charge to assess the NHS England SDE, which can be viewed here: https://digital.nhs.uk/services/secure-data-environment-service"}]},{"type":"paragraph","content":[{"type":"text","marks":[{"type":"bold"}],"text":"SAFE People - Login & Access"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Applicant Organisations accredited via DSPT" (suggest expanding acronym)"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Data Access by Applicant Organisation restricted by Data Sharing Agreement (DSA)"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Applicant Organisation responsible for accrediting end users operating under a DSA"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ End User Access Agreement defines acceptable/expected behaviours"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Login: Browser based login using 2FA"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ International Access: At a technology-level yes. There are direction sharing agreement restrictions on the use of (some) data"}]},{"type":"paragraph","content":[{"type":"text","marks":[{"type":"bold"}],"text":"SAFE Settings - Compute & Services"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Data hosted securely on NHSE-managed Amazon Web Services (AWS) accounts"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Dedicated analysis environment provisioned specifically for each Data Sharing Agreement (DSA)"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Users operating in one analysis environment have no access to other environments or the public internet"}]},{"type":"paragraph","content":[{"type":"text","marks":[{"type":"bold"}],"text":"SAFE Settings - Security Certifications and Measures"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Automated scanning & benchmarking against Centre for Internet Security guidelines"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Static code analysis integrated into build pipelines"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Infrastructure monitored 24/7 by NHSE Cyber Security Operations Centre (CSOC)"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Dedicated cyber security allocated to support delivery team"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Penetration Testing conducted after every significant architectural change"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Independent Threat Modelling exercise conducted"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Developers with access to production environment are subject to security vetting"}]},{"type":"paragraph","content":[{"type":"text","text":"SAFE Settings - Software access"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Direct access to provisioned data only possible via Databricks platform."}]},{"type":"paragraph","content":[{"type":"text","text":"✓ All queries executed via Databricks recorded & auditable in Immuta (access control & auditing component/product)"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Code packages/libraries made available in the environment are subject to review / approval process"}]},{"type":"paragraph","content":[{"type":"text","marks":[{"type":"bold"}],"text":"SAFE Data - Data Access Mechanisms"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Data minimised and provisioned in accordance with the approved Data Sharing Agreement (DSA)"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Data only accessible from DSA-specific analysis environment; data cannot be transferred between analysis environments"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Identifiable fields pseudonymised in accordance with the DSA."}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Unique pseudo key used for each DSA (a given value will be represented differently in each agreement)"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Fields containing sensitive data removed from data asset prior to data provisioning process"}]},{"type":"paragraph","content":[{"type":"text","marks":[{"type":"bold"}],"text":"SAFE Outputs - Data Output/export"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ SDE service allows research (with small number suppression) results to be safely exported. This is via an escrow function manned by NHS England employees who examine the artefacts prior to release to the user – based upon an approved, principles-based disclosure control output policy. Patient / row level data cannot be exported."}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Export plans: NHSE are currently exploring a range of safe data outputs types and welcome the opportunity of brining NCS projects into this exploration. We anticipate being able to allow user’s code to be exported in the future."}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Data transmit to other SAFE Settings: We do not provide this service at present. However, ad-hoc requests can be considered via a Service Request"}]},{"type":"paragraph","content":[{"type":"text","text":"✓ Statistical disclosure control process in place"}]}]}

https://digital.nhs.uk/services/secure-data-environment-service

Datasets (36)

Mental Health Services Data Set - Community

Dataset population size: Unknown

Health and disease

MSDS (Maternity Services Data Set)

Dataset population size: 58,035

Health and disease

Mental Health & Learning Disabilities Dataset v 1 (Sensitive) Events

Dataset population size: Unknown

Health and disease

Mental Health & Learning Disabilities Dataset v 1 (Non-Sensitive) Episodes

Dataset population size: Unknown

Health and disease

Community Services Data Set

Dataset population size: 778,520

Health and disease

Secondary Uses Services Payment By Results

Dataset population size: Unknown

Health and disease

Datasets

Collections (1)

NHS DigiTrials: Clinical Trials

Analysis Scripts & Software (0)

Data Uses (165)

Comparing COVID-19 Vaccine Schedule Combinations (Com-COV)

University of Oxford

A Phase II, randomised, single-blind, platform trial to assess safety, reactogenicity and immunogenicity of COVID-19 vaccines in pregnant women in the United Kingdom (Preg-CoV)

St George's, University of London

Patterning of children and young peoples' mental health before and in the context of Covid-19: findings from the 2017 Mental Health of Children and Young People survey and the 2020 MHCYP Covid-19 follow up survey

NatCen Social Research

Phase II/III Study of AZD2816, a Vaccine for the Prevention of COVID-19 in Adults

AstraZeneca UK Limited

National Gastrointestinal Cancer Audit Programme

Royal College of Surgeons

Comparing COVID-19 Vaccine Schedule Combinations – Stage 2 (Com-COV2)

University of Oxford

Publications (70)

Overall and cause-specific hospitalisation and death after COVID-19 hospitalisation in England: cohort study in OpenSAFELY using linked primary care, secondary care and death registration data

Bhaskaran K, Rentsch CT, Hickman G, Hulme WJ, Schultze A, Curtis HJ, Wing K, Warren-Gash C, Tomlinson L, Bates CJ, Mathur R, MacKenna B, Mahalingasivam V, Wong A, Walker AJ, Morton CE, Grint D, Mehrkar A, Eggo RM, Inglesby P, Douglas IJ, McDonald HI, Cockburn J, Williamson EJ, Evans D, Parry J, Hester F, Harper S, Evans SJ, Bacon S, Smeeth L, Goldacre B.

Risk factors for long COVID: analyses of 10 longitudinal studies and electronic health records in the UK

Thompson EJ, Williams DM, Walker AJ, Mitchell RE, Niedzwiedz CL, Yang TC, Huggins CF, Kwong ASF, Silverwood RJ, Gessa GD, Bowyer RC, Northstone K, Hou B, Green MJ, Dodgeon B, Doores KJ, Duncan EL, Williams FMK, OpenSAFELY Collaborative, Steptoe A, Porteous DJ, McEachan RRC, Tomlinson L, Goldacre B, Patalay P, Ploubidis GB, Katikireddi SV, Tilling K, Rentsch CT, Timpson NJ, Chaturvedi N, Steves CJ.

Rates of serious clinical outcomes in survivors of hospitalisation with COVID-19: a descriptive cohort study within the OpenSAFELY platform

The OpenSAFELY Collaborative, Tazare J, Tazare J, Walker AJ, Tomlinson L, Hickman G, Rentsch CT, Williamson EJ, Bhaskaran K, Evans D, Wing K, Mathur R, Wong AY, Schultze A, Bacon S, Bates C, Morton CE, Curtis HJ, Nightingale E, McDonald HI, Mehrkar A, Inglesby P, Davy S, MacKenna B, Cockburn J, Hulme WJ, Hulme WJ, Warren-Gash C, Bhate K, Nitsch D, Powell E, Mulick A, Forbes H, Minassian C, Croker R, Parry J, Hester F, Harper S, Eggo RM, Evans SJ, Smeeth L, Douglas IJ, Goldacre B.

Short report: Ethnicity and COVID-19 death in the early part of the COVID-19 second wave in England: an analysis of OpenSAFELY data from 1<sup>st</sup> September to 9<sup>th</sup> November 2020

Bhaskaran K, Mathur R, Rentsch CT, Morton CE, Hulme WJ, Schultze A, MacKenna B, Eggo RM, Wong AY, Williamson EJ, Forbes H, Wing K, McDonald HI, Bates C, Bacon S, Walker AJ, Evans D, Inglesby P, Mehrkar A, Curtis HJ, DeVito NJ, Croker R, Drysdale H, Cockburn J, Parry J, Hester F, Harper S, Douglas IJ, Tomlinson L, Evans SJ, Grieve R, Smeeth L, Goldacre B.

Changes in the rate of cardiometabolic and pulmonary events during the COVID-19 pandemic

Walker AJ, Tazare J, Hickman G, Rentsch CT, Williamson EJ, Bhaskaran K, Evans D, Wing K, Mathur R, Wong AY, Schultze A, Bacon SC, Bates C, Morton CE, Curtis HJ, Nightingale E, McDonald HI, Mehrkar A, Inglesby P, MacKenna B, Cockburn J, Hulme WJ, Forbes H, Minassian C, Croker R, Parry J, Hester F, Harper S, Eggo RM, Evans SJ, Smeeth L, Douglas IJ, Tomlinson L, Goldacre B.

Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study.

Nyberg T, Ferguson NM, Nash SG, Webster HH, Flaxman S, Andrews N, Hinsley W, Bernal JL, Kall M, Bhatt S, Blomquist P, Zaidi A, Volz E, Aziz NA, Harman K, Funk S, Abbott S, COVID-19 Genomics UK (COG-UK) consortium, Hope R, Charlett A, Chand M, Ghani AC, Seaman SR, Dabrera G, De Angelis D, Presanis AM, Thelwall S.